Evaluation of Oxidative Stress and some Biochemical Parameters in Normal Pregnant Women

Keywords: Pregnancy, Oxidative stress, Liver parameters, Lipid profiles, Kidney function


Pregnancy is associated with many metabolic changes in normal pregnant woman, this leads to change in physiological, biochemical, and hematological parameters drastically. The test subjects were selected among those attending to Maternity Teaching Hospital in Erbil Governorate between March 2017 and August 2017. Four groups of individuals were included in this study, 230 pregnant women divided into three groups (Group 1 first trimester, Group 2 second trimester, and Group 3 third trimester) and Group 4 contained 90 nonpregnant women as control. Full automatic chemical analyzer (Cobas C311, Germany) was used to determine the biochemical parameters. The EL ×800 Absorbance Microplate Reader from BioTek (USA) instruments is used to measure the activity of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in serum. The results of this study showed a significant increase in serum albumin, glucose, total bilirubin, direct bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine, urea, cholesterol, low-density lipoprotein, and MDA in pregnant women as compared to the control group, also show significant decrease in high-density lipoprotein (HDL) level, SOD activity, and CAT activity in pregnant women as compared to nonpregnant women, and nonsignificant difference in uric acid, and HDL.


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Author Biographies

Musher I. Kakey, Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region

Musher is an assistant lecturer at the Department of Chemistry, Faculty of Science and Health, Koya University. He has received his B.Sc. in Chemistry at Koya University in 2010 and his MSc. at the University in 2014. He has 6 published articles.

Kamaran K. Abdoulrahman, Department of Chemistry, College of Science, Salahaddin University, Erbil, Kurdistan Region

Kamaran Kaiani Abdoulrahman is Assistant Professor at the Department of Chemistry of College of Science, Salahaddin University. He got his B.Sc. and M.Sc. degree in GKarl Franzens University Graz, Austria and the Ph. D. degree in Vienna University. His research interests are in Clinical Biochemistry and molecular biology.

Gulbahar R. Uthman, Department of Chemistry, College of Science, Salahaddin University, Erbil, Kurdistan Region

Gulbahar Rostam Uthman is Laboratory Assistant at Rezgary Hospital, Erbil. She got her B. Sc. degree in Chemistry in Salahaddin University in 2017. Her research interests are in Clinical Biochemistry. Gulbahar Rostam Uthman is a member Kurdistan Chemistry Sandicate.


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How to Cite
Kakey, M. I., Abdoulrahman, K. K. and Uthman, G. R. (2020) “Evaluation of Oxidative Stress and some Biochemical Parameters in Normal Pregnant Women”, ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 8(1), pp. 17-23. doi: 10.14500/aro.10541.