Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies

Jihad H. Mohammed; Akram N. M.  Qaddo; Nabaz A. Muhammad Salih; Faeza B. Omar

doi:10.14500/aro.11471

Jihad H. Mohammed Department of Chemistry, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq https://orcid.org/0009-0004-3248-8714
Akram N. M. Qaddo Department of Chemistry, Education College for Girls, University of Mosul – F.R. Iraq https://orcid.org/0000-0003-1833-575X
Nabaz A. Muhammad Salih Department of Chemistry, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq https://orcid.org/0009-0000-6233-6077
Faeza B. Omar Department of Biology, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq https://orcid.org/0000-0002-0322-9498

Keywords: Aromatic oximes, Azomethine-N-oxide, Biological activity, Condensation reaction

Abstract

The organic compound category known as azomethine oxides has garnered significant attention due to its potential for bioactive and pharmacological effects, as well as its role in organic syntheses. Existing literature offers various methods for producing derivatives of these compounds. This study, in particular, concentrates on the creation of several aromatic oximes through the reduction of corresponding aldehydes. Furthermore, these oximes are employed in the generation of new azomethine oxides through a condensation reaction with selected aldehydes. The molecular structure of the synthesized azomethine oxides is determined using techniques such as Fourier-transform infrared spectroscopy, ¹H-NMR, and ¹³C-NMR. Finally, the antimicrobial effectiveness of these compounds was assessed against Escherichia coli (gram-negative bacteria), Staphylococcus aureus (gram-positive bacteria), and Candida albicans (fungus). The synthesized compounds were obtained with high purity and yielded excellent results. Furthermore, the data demonstrates that these azomethine oxides exhibit significant antimicrobial activity when compared to standard drugs.

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Author Biographies

Jihad H. Mohammed, Department of Chemistry, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq

Jihad H. Mohammed has a B.Sc degree in Chemistry.

Akram N. M. Qaddo, Department of Chemistry, Education College for Girls, University of Mosul – F.R. Iraq

Akram N. M. Qaddo is a Lecturer at the Department of Chemistry, Education College for Girls, University of Mosul, Iraq. He got the B.Sc degree in Chemistry, the M.Sc. degree in Organic Chemistry and the Ph.D. degree in Organic Chemistry. His research interests are in Organic Syntheses, Organometalic syntheses and OrganoZinc Chemistry.

Nabaz A. Muhammad Salih, Department of Chemistry, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq

Nabaz A. Muhammad Salih is an Assistant Professor at the Department of Chemistry, Faculty of Science, Soran University, Kurdistan Region, Iraq. He got the B.Sc degree in Chemistry, the M.Sc. degree in Organic Chemistry and the Ph.D. degree in Organic Chemistry. His research interests are in Organic Syntheses, Organometalic syntheses and OrganoZinc Chemistry.

Faeza B. Omar, Department of Biology, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq

Faeza B. Omar has a B.Sc degree in Biology.

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