New Fluorescence Quenching Approach for Determination of Valsartan in Certain Tablets and Spiked Biological Fluids

  • Layth I. Abd Ali Department of Chemistry, Faculty of Science and Health, Koya University, Daniel Mitterrand Boulevard, Koya KOY45 AB64, Kurdistan Region – F.R. Iraq http://orcid.org/0000-0002-5948-2513
Keywords: Basic fuchsin, Fluorescence quenching, Pharmaceutical analysis, Valsartan

Abstract

A new, simple, selective, sensitive, fast, economical, and reliable fluorescence quenching method for the quantitation of valsartan was investigated using basic fuchsin act as a fluorometric dye. The method was depended on the detection quenching influence of valsartan on the fluorescence intensity of basic fuchsin and the reaction between valsartan and basic fuchsin in a McIlvaine buffer medium at pH = 6 to yield a new basic fuchsin–valsartan non-fluorescent complex. The excitation and emission of basic fuchsin fluorescence signal were identified at 535 and 728 nm, respectively. A fluorescence quenching value (ΔF) displayed a very good linear relationship (R2 = 0.9992) with valsartan concentration ranging from 0.003 to 3 μg/mL, a detection limit as low as 0.0009 μg/mL with a high precision and accuracy (RSD% <3). Significantly, no interference effect was found due to the presence of other ingredients commonly found in medical formulations. The acquired data were statistically compared with those acquired from reported chromatographic method and were observed to be in excellent agreement at a 95% confidence level; the planned fluorescence quenching procedure was subsequently utilized to detected the concentration of valsartan in spiked biological fluids and commercial medical tablets.

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Author Biography

Layth I. Abd Ali, Department of Chemistry, Faculty of Science and Health, Koya University, Daniel Mitterrand Boulevard, Koya KOY45 AB64, Kurdistan Region – F.R. Iraq

Layth I. Abd Ali Daabel is a Lecturer of Analytical Chemistry in the Chemistry Department, Faculty of Science and Health. He joined the work at Koya University since 2010 as Assistant Lecturer. He gained a B.Sc. degree in Chemistry from Collage of Science, Kufa University in 1999, M.Sc. degree in Analytical Chemistry from Al-Mustansiriya University in 2007.and Ph.D. degree in Analytical Chemistry from UTM, Malaysia, in 2016. He has (1) patent (5) published Journal papers, and (8) conference papers. His research interests ar; Analytical chemistry, Separation methods, Trace metal analysis, Magnetic nano-particles, Pharmaceutical analysis. [see TAP] e-mail: layth.imad@koyauniversity.org

References

Annadi, A.M., El Sheikh, R. and Mohamed, A.A., 2019. Development and validation of a LC-MS/MS method for the determination of valsartan in human plasma after protein precipitation or liquid-liquid extraction. Analytical Chemistry Letters, 9(4), pp.504-517.

Azadi, A. and Ahmadi, S., 2019. Simultaneous magnetic dispersive micro solid phase extraction of valsartan and atorvastatin using a CMC-coated Fe3 O4 nanocomposite prior to HPLC-UV detection: Multivariate optimization. New Journal of Chemistry, 43, pp.16950-16959.

Babarahimi, V., Talebpour, Z., Haghighi, F., Adib, N. and Vahidi, H., 2018. Validated determination of losartan and valsartan in human plasma by stir bar sorptive extraction based on acrylate monolithic polymer, liquid chromatographic analysis and experimental design methodology. Journal of Pharmaceutical and Biomedical Analysis, 153, pp.204-213.

Cagigal, E., Gonzalez, L., Alonso, R.M. and Jimenez, R.M., 200. Experimental design methodologies to optimise the spectrofluorimetric determination of Losartan and Valsartan in human urine. Talanta, 54(6), pp.1121-33.

Carlucci, G., Carlo, V.D. and Mazzeo, P., 2000. Simultaneous determination of valsartan and hydrochlorothiazide in tablets by high-performance liquid chromatography. Analytical Letters, 33(12), pp.2491-2500.

del Rosario Brunetto, M., Contreras, Y., Clavijo, S., Torres, D., Delgado, Y., Ovalles, F., Ayala, C., Gallignani, M., Estela, J.M. and Martin, V.C., 2009. Determination of losartan, telmisartan, and valsartan by direct injection of human urine into a column-switching liquid chromatographic system with fluorescence detection. Journal of Pharmaceutical and Biomedical Analysis, 50(2), pp.194-199.

Dinc, E., Ertekin, Z.C. and Buker, E., 2017. Multiway analysis methods applied to the fluorescence excitation-emission dataset for the simultaneous quantification of valsartan and amlodipine in tablets. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 184, pp.255-261.

Dinc, E., Uslu, B. and Özkan, S.A., 2004. Spectral resolution of a binary mixture containing valsartan and hydrochlorothiazide in tablets by ratio spectra derivative and inverse least square techniques. Analytical Letters, 37(4), pp.679-693.

Eisele, A.P.P., Mansano, G.R., de Oliveira, F.M., Casarin, J., Tarley, C.R.T. and Sartori, E.R., 2014. Simultaneous determination of hydrochlorothiazide and valsartan in combined dosage forms: Electroanalytical performance of cathodically pretreated boron-doped diamond electrode. Journal of Electroanalytical Chemistry, 732, pp.46-52.

Eissa, M.S. and Abou Al Alamein, A.M., 2018. Innovative spectrophotometric methods for simultaneous estimation of the novel two-drug combination: sacubitril/valsartan through two manipulation approaches and a comparative statistical study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 193, pp.365-374.

El-Kosasy, A.M., Tawakkol, S.M., Ayad, M.F. and Sheta, A.I., 2015. New methods for amlodipine and valsartan native spectrofluorimetric determination, with factors optimization study. Talanta, 143, pp. 402-413.

El-Shaboury, S.R., Hussein, S.A., Mohamed, N.A. and El-Sutohy, M.M., 2012. Spectrofluorimetric method for determination of some angiotensin II receptor antagonists. Journal of Pharmaceutical Analysis, 2(1), pp.12-18.

Erk, N., 2002. Spectrophotometric analysis of valsartan and hydrochlorothiazide. Analytical Letters, 35(2), pp.283-302.

Farajzadeh, M.A., Khorram, P. and Pazhohan, A., 2016. Simultaneous determination of atorvastatin and valsartan in human plasma by solid-based disperser liquid-liquid microextraction followed by high-performance liquid chromatography-diode array detection. Journal of Chromatography B, 1017, pp.62-69.

Gadepalli, S.G., Deme, P., Kuncha, M. and Sistla, R., 2014. Simultaneous determination of amlodipine, valsartan and hydrochlorothiazide by LC–ESI-MS/MS and its application to pharmacokinetics in rats. Journal of Pharmaceutical Analysis, 4(6), pp.399-406.

Gong, A.Q. and Zhu, X.S. 2013. Determination of epristeride by its quenching effect on the fluorescence of L-tryptophan. Journal of Pharmaceutical Analysis, 3(6), pp.415-420.

Graham, J.P., Rauf, M.A., Hisaindee, S. and Alzamly, A., 2017. Spectral behavior and computational studies of fuchsin in various solvents. Journal of Molecular Liquids, 238, pp.193-197.

Ibrahim, F.A., El-Brashy, A.M., El-Awady, M.I. and Abdallah, N.A., 2018. Fast simultaneous quantitation of valsartan and amlodipine besylate using an eco-friendly micellar HPLC-UV method: Application to spiked human plasma and content uniformity testing for amlodipine. Analytical Methods, 10(43), pp.5227-5235.

Kaabipour, M., Khodadoust, S. and Zeraatpisheh, F. 2020. Preparation of magnetic molecularly imprinted polymer for dispersive solid-phase extraction of valsartan and its determination by high-performance liquid chromatography: Box‐Behnken design. Journal of Separation Science, 43, pp.912-919.

Kamal, A.H., Marie, A.A. and Hammad, S.F., 2020. Validated spectrophotometric methods for simultaneous determination of nebivolol hydrochloride and valsartan in their tablet. Microchemical Journal, 155, p.104741.

Koseki, N., Kawashita, H., Hara, H., Niina, M., Tanaka, M., Kawai, R., Nagae, Y. and Masuda, N., 2007. Development and validation of a method for quantitative determination of valsartan in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 43(5), pp.1769-1774.

Krishnaiah, C., Reddy, A.R., Kumar, R. and Mukkanti, K., 2010. Stabilityindicating UPLC method for determination of Valsartan and their degradation products in active pharmaceutical ingredient and pharmaceutical dosage forms. Journal of Pharmaceutical and Biomedical Analysis, 53(3), pp.483-489.

Kumar, L., Sreenivasa Reddy, M., Managuli, R.S. and Pai, K.G., 2015. Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles. Saudi Pharmaceutical Journal, 23(5), pp.549-555.

Lakowicz, J.R. 2013. Principles of Fluorescence Spectroscopy. Springer Science and Business Media, Berlin, Germany.

Lotfy, H.M., Hegazy, M.A., Mowaka, S. and Mohamed, E.H., 2015. Novel spectrophotometric methods for simultaneous determination of amlodipine, valsartan and hydrochlorothiazide in their ternary mixture. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 140, pp.495-508.

Macek, J., Klima, J. and Ptacek, P., 2006. Rapid determination of valsartan in human plasma by protein precipitation and high-performance liquid chromatography. Journal of Chromatography B, 832(1), pp.169-172.

Mansano, G.R., Eisele, A.P.P., Dall’Antonia, L.H., Afonso, S. and Sartori, E.R., 2015. Electroanalytical application of a boron-doped diamond electrode: Improving the simultaneous voltammetric determination of amlodipine and valsartan in urine and combined dosage forms. Journal of Electroanalytical Chemistry, 738, pp.188-194.

Marghany, K.A., Abdelsalam, R.A. and Haddad, G.M., 2020. HPLC method transfer study for simultaneous determination of seven angiotensin II receptor blockers. Journal of Separation Science, 43, pp.1398-1405.

Meselhy, E.M., Aboul Kheir, A.A., El Henawee, M.M. and Elmasry, M.S., 2020. Simultaneous determination of Nebivolol hydrochloride and Valsartan in their binary mixture using different validated spectrophotometric methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 230, pp.118083.

Moussa, B.A., Hashem, H.M.A., Mahrouse, M.A. and Mahmoud, S.T., 2018. A validated RP-HPLC method for the determination of rosuvastatin in presence of sacubitril/valsartan in rat plasma: Application to in vivo evaluation of OATPmediated drug interaction potential between rosuvastatin and sacubitril/valsartan. Microchemical Journal, 143, pp.31-38.

Ning, J., Wang, M., Luo, X., Hu, Q., Hou, R., Chen, W., Chen, D., Wang, J. and Liu, J., 2018. SiO2 stabilized magnetic nanoparticles as a highly effective catalyst for the degradation of basic fuchsin in industrial dye wastewaters. Molecules, 23(10), pp.2573.

Pathrose, B., Nampoori, V.P.N., Radhakrishnan, P., Sahira, H. and Mujeeb, A., 2016. Effect of femtosecond laser ablated silver nanoparticles in the thermo-optic properties of basic fuchsin dye. Optik, 127(7), pp.3684-3687.

Pathrose, B., Nampoori, V.P., Radhakrishnan, P. and Mujeeb, A., 2014. Measurement of absolute fluorescence quantum yield of basic fuchsin solution using a dual-beam thermal lens technique. Journal of Fluorescence, 24(3),pp.895-898.

Pathrose, B., Sahira, H., Nampoori, V.P., Radhakrishnan, P. and Mujeeb, A.,2014. Variations in fluorescence quantum yield of Basic Fuchsin with silver nanoparticles prepared by femtosecond laser ablation. Spectrochimica Acta PartA: Molecular and Biomolecular Spectroscopy, 128, pp.522-526.

Pebdani, A.A., Dadfarnia, S., Shabani, A.M.H., Khodadoust, S. and Haghgoo, S., 2016. Application of modified stir bar with nickel: Zinc sulphide nanoparticles loaded on activated carbon as a sorbent for preconcentration of losartan andvalsartan and their determination by high performance liquid chromatography. Journal of Chromatography A, 1437, pp.15-24.

Qader, A., Salih, M., Tahir, T., 2018. Quantitativ e Quenching of Fluorescein Based Method for Determination of Valsartan in Some Pharmaceutical Product. In: Proceeding of the 2018 International Conference on Pure and Applied Science, Koya University, 23-24 April 2018. Available from: http://www.conferences.koyauniversity.org/index.php/pas/2018/paper/view/92>. [Last accessed on 2020 Oct 10].

Ragab, M.A.A., Galal, S.M., Korany, M.A. and Ahmed, A.R., 2017. First derivative emission spectrofluorimetric method for the determination of LCZ696, a newly approved FDA supramolecular complex of valsartan and sacubitril in tablets. Luminescence, 32(8), pp.1417-1425.

Ragab, M.A.A., Korany, M.A., Galal, S.M. and Ahmed, A.R., 2019. Voltammetric study of valsartan-Ni complex: Application to valsartan analysis in pharmaceuticals and in vivo human urine profiling. Chemical Papers, 73(5), pp.1209-1219.

Satana, E., Altinay, S., Goger, N.G., Ozkan, S.A. and Senturk, Z., 2001. Simultaneous determination of valsartan and hydrochlorothiazide in tablets by first-derivative ultraviolet spectrophotometry and LC. Journal of Pharmaceutical and Biomedical Analysis, 25(5-6), pp.1009-1013.

Selvan, P.S., Gowda, K.V., Mandal, U., Solomon, W.D. and Pal, T.K., 2007. Simultaneous determination of fixed dose combination of nebivolol and valsartan in human plasma by liquid chromatographic-tandem mass spectrometry and its application to pharmacokinetic study. Journal of Chromatography B, 858(1-2), pp.143-150.

Shaalan, R.A. and Belal, T.S., 2010. Simultaneous spectrofluorimetric determination of amlodipine besylate and valsartan in their combined tablets. Drug Testing and Analysis, 2(10), pp.489-493.

Shah, J.V., Parekh, J.M., Shah, P.A., Shah, P.V., Sanyal, M. and Shrivastav, P.S., 2017. Application of an LC–MS/MS method for the analysis of amlodipine, valsartan and hydrochlorothiazide in polypill for a bioequivalence study. Journal of Pharmaceutical Analysis, 7(5), pp.309-316.

Shaikh, J.S.A., Raut, S., Abdul, A. and Pathan, M., 2020. High performance liquid chromatographic assay of amlodipine, valsartan and hydrochlorothiazide simultaneously and its application to pharmaceuticals, urine and plasma analysis. Journal of Chromatography B, 1155, pp.122295.

Shalan, S., El-Enany, N. and Belal, F., 2015. Simultaneous determination of amlodipine besylate and valsartan using a micelle-enhanced first derivative synchronous spectrofluorimetric method and application in their co-formulated tablets. Analytical Methods, 7(19), pp.8060-8068.

Tatar, S. and Saglik, S., 2002. Comparison of UV-and second derivativespectrophotometric and LC methods for the determination of valsartan in pharmaceutical formulation. Journal of Pharmaceutical and Biomedical Analysis, 30(2), pp.371-375.

Vojta, J., Jedlicka, A., Coufal, P. and Janeckova, L., 2015. A new, rapid, stabilityindicating UPLC method for separation and determination of impurities in amlodipine besylate, valsartan and hydrochlorothiazide in their combined tablet dosage form. Journal of Pharmaceutical and Biomedical Analysis, 109, pp.36-44.

Published
2020-12-28
How to Cite
Abd Ali, L. I. (2020) “New Fluorescence Quenching Approach for Determination of Valsartan in Certain Tablets and Spiked Biological Fluids”, ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 8(2), pp. 82-90. doi: 10.14500/aro.10761.