Hemodynamic, Thyroid and Immunomodulatory Effects of Heroin in Rats

  • Ismail M. Maulood Department of Biology, College of Science, Salahaddin University.
Keywords: Blood pressure, Heroin, MCP-1, Thyroxine, Troponin-T


Diacetylmorphine (heroin) has many effects on the body system; it exerts effects on cardiovascular, immune and endocrine systems. The aim of the this study is to investigate the short-term effects of low and high doses of heroin on systolic blood pressure (SBP), thyroid hormones and monocyte chemoattractant protein-1 (MCP-1). The experimental rats were divided into three groups, each with six individuals and the treatments were continued for seven days.  SBP significantly reduced by heroin administration in the second dose as compared with the control group.   A marked decrease in the serum NO level was also noticed after first (low) and second (high) dose of administration as compared with control group.  The present results also revealed that serum MCP-1 was statistically increased in the second dose of heroin group. Statistical analysis showed that both serum T3 and T4 levels were reduced significantly by heroin administration. In conclusions, for the first time, our findings suggested that diacetylmorphine could affect immune system through MCP-1 elevation. As well as heroin may affect cardiac and liver functions via increasing troponin-T and bilirubin levels.


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Author Biography

Ismail M. Maulood, Department of Biology, College of Science, Salahaddin University.
Ismail M. Maulood is a lecturer at the Department of Biology/College of Science/ Salahaddin University-Erbil since 1996. He has a M.Sc. and Ph. D. in Animal physiology. He is an Assist. Prof. from 2010 till now. He has 15 publications mostly around melatonin and Endothelin hormones. His Scientific and Academic committees partaken are: Examining committee of B. Sc. students , Participation in examining committee of M. Sc. and Ph. D thesis as well as supervising B. Sc. , M. Sc. and Ph. D students. He was a Membership of International Brain Research organization (IBRO) in USA as well as Membership of Biology syndicate.


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How to Cite
Maulood, I. M. (2016) “Hemodynamic, Thyroid and Immunomodulatory Effects of Heroin in Rats”, ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 4(1), pp. 43-47. doi: 10.14500/aro.10097.