Hematological, Biochemical and Blood Lead Level Profile among Gasoline Exposed Station Workers in Sulaimaniya City
Abstract
Occupational exposure to toxic fumes of leaded gasoline has become a major public health concern. These fumes contain tremendous life threatening toxins, which can cause abnormal alterations in the functioning of many vital organs. The current study intended to find out any changes in the hematological and biochemical profile in correlation to the Blood lead levels among individuals occupationally exposed to gasoline and gasoline vapors as a fist line risk group. The mean Blood lead level among gasoline station workers (6.2±5µg/dL), was significantly higher (P=0.017) than controls (2.1 ± 6.4 µg/dL), and there was a significant (P=0.003) increase in Blood lead level (10.6±3.9 µg/dL) of smoking workers compared to non-smoking workers. The latter is above the permitted value for adult individuals. The workers had higher (P=0.01) concentration of hemoglobin (15.9 gm/dL), whereas, other hematological counts were within the normal limits. Serum alkaline phosphatase and uric acid were significantly higher among the workers (338±49.5 and 6.1±1.7) with P-value of (0.0001 and 0.038 respectively), whereas, no statistically significant differences were found among serum alanine transaminase, aspartate transaminase, creatinine, cholesterol and albumin.Downloads
References
Abdel Aziz, I.I., Al Agha, S.Z. and Shehwan, O.A., 2006. Hematological and Biochemical Studies for Gasoline Toxicity among Gasoline Workers in Gaza Strip. Al-Aqsa Univ. J., (10), pp.41-55.
Alasia, D.D., Emem-Chioma, P.C. and Wokoma, F.S., 2010. Association of Lead Exposure, Serum Uric Acid and Parameters of Renal Function in Nigerian Lead- Exposed Workers. Int. J. Occup. Environ. Med., 1(4), pp.182-190.
Ali Khan, A., Sultan, R., Zamani, GY. and Rahman, S.U., 2013. Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making. Journal of Biology and Life Science, 4(2), pp.116-28.
Al-Rudainy, L.A., 2010. Blood Lead Level among Fuel Station Workers. Oman Medical Journal, 25(3), pp.208-211.
Amal, K., 2009. Impact of gasoline inhalation on some neurobehavioral characteristics of male rats. BMC Physiology, (9)21, doi:10.1186/1472-6793-9-21
Amal, M., Akhlaque, H., Manirul, I. and Bashar, S.A., 2009. Lead Poisoning: An Alarming Public Health Problem in Bangladesh. Int. J. Environ. Res. Public Health, 6(1), pp.84-95.
Baan, R., Grosse, Y., Straif, K., Secretan, B., El-Ghissassi, F., Bouvard, V., et al., 2009. A review of human carcinogens—Part F: chemical agents and related occupations. Lancet Oncol., 10(12), pp.1143–1144.
Cabaravdic, M., Mirjana, M., Jasna, K., and Amra. 2010. Occupational Exposure of Workers at Gas Station to Inorganic Lead. MED ARH, 64(2), pp.107-109.
Carugno, M., Pesatori, AC., Dioni, L., Hoxha, M., Bollati, V., Albetti, B., Byun, HM., Bonzini, M., Fustinoni, S., Cocco, P., Satta, G., Zucca, M., Merlo, DF., Cipolla, M., Bertazzi, PA. and Baccarelli, A., 2012. Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposure. Environmental Health Perspectives. 120(2), pp.210-215.
Centers of Disease Control and Protection (CDC), 2013. Blood Lead Levels in Children Aged 1–5 Years—United States, 1999–2010. MMWR, (62), pp.245-248.
Department of Health and Human Services, 2007. Toxicological Profile for Lead. [pdf] U.S.: Agency for Toxic Substances and Disease Registry. Available at <http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf> [Accessed 1 November 2013].
Elwood, P.C. and Gallacher, J.E., 1984. Lead in petrol and levels of lead in blood: scientific evidence and social policy. Journal of Epidemiology and Community Health. 38(4), pp.315-318.
Grandjean, P., Niels, B.P. and Hanne, H., 1981. Influence of smoking and alcohol on blood lead levels. Int. Arch Occup Environ health. 48(4), pp.391-397.
Hamad, A.R., 2008. Some Biochemical and Hematological Alterations Associated with Lead Exposure in Gasoline Station Workers in Gaza Strip. M.Sc.thesis, the Islamic University-Gaza, Faculty of Science., pp.37-58.
Hernández-Serrato, M.I., Mendoza-Alvarado, L.R., Rojas-Martínez, R., González-Garza, C., Hulme, J.M. and Olaiz-Fernández, G., 2003. Factors associated with lead exposure in Oaxaca, Mexico. Journal of Exposure Analysis and Environmental Epidemiology. 13(5), pp.341-347.
Karrari, P., Mehrpour O. and Abdollahi M. A., 2012. Systematic review on status of lead pollution and toxicity in Iran; Guidance for preventive measures. DARU Journal of Pharmaceutical Sciences, 20(1), doi: 10.1186/1560-8115-20-2.
Lynda, A., Mohamed, H., Abderrezek, T. and Seddik K., 2011. Effect of Long-term Exposure to Low or Moderate Lead Concentrations on Growth, Lipid Profile and Liver Function in Albino Rats. Advances in Biological Research. 5(6), pp. 339-347.
Mahmoud, L.A., 1997. Renal Effects of Environmental and Occupational Lead Exposure. Envinm Healh Perspect., 105(9), pp.928-939.
Ni, Z., Hou, S., Barton, CH. and Vaziri, ND., 2004. Lead exposure raises superoxide and hydrogen peroxide in human endothelial and vascular smooth muscle cells. Kidney International. 66(6), pp.2329–2336.
Nordic Council of Ministers, 2003. Lead Review. Available at <http://www.who.int/ifcs/documents/forums/forum5/nmr_lead.pdf>
[Accessed 1 November 2013].
Odigie, I.P., Ladipo, C.O., Ettarh, R.R and Zebu, M.C., 2004. Effect of Chronic Exposure to Low Levels of Lead on Renal Function and Renal Ultrastructure in Sd Rats. Nigerian Journal of Physiological Sciences, 19(1-2), pp.27-32.
Pesatori, A.C., Garte, S., Popov, T., Georgieva, T., Panev, T., Bonzini, M., Consonni, D., Carugno, M., Goldstein, B.D., Taioli, E., Fontana, V., Stagi, E., Bertazzi, P.A. and Merlo, D. F., 2009 . Early effects of low benzene exposure on blood cell counts in Bulgarian petrochemical workers. Medicina Del Lavoro, 100(2), pp.83-90.
Rahman, S.U., 2013. Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making. Journal of Biology and Life Science., 4(2), pp.116-28.
U.S. Environmental Protection Agency, 2009. Benzene TEACH Chemical Summary. [pdf] U.S.: EPA, Toxicity and Exposure Assessments for Children’s Health.
Available at <http://www.epa.gov/teach/chem_summ/BENZ_summary.pdf> [Accessed 1 November 2013].
Uzma, N., Salar, B.M.K.M., Kumar, B.S., Aziz, N., David, M.A. and Reddy, V.D., 2008. Impact of organicsolvents and environmental pollutants on the physiological function in petrol filling workers. International Journal of Environmental Research and Public Health, 5(3), 139-46.
WHO, 2010. Exposure to Benzene: A Major Public Health Concern. [pdf] Geneva: WHO, Dept. of Public Health and Environment.
Available at <http://www.who.int/ipcs/features/benzene.pdf> [Accessed 1 November 2013].
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