Male Rat Susceptibility for Liver and Kidney Injury

Sarkawt Hamad; Karwan I. Othman; Karwan J. Hamad; Balkes H. Rasul; Shorsh M. Abdulla; Ismael A. Ismael

doi:10.14500/aro.10087

Sarkawt Hamad Department of Biology, Faculty of Science, Soran University, Kurdistan Region.
Karwan I. Othman Ashti Hospital, Soran, Erbil, Ministry of Health, Kurdistan Region.
Karwan J. Hamad Department of Biology, Faculty of Science, Soran University, Kurdistan Region.
Balkes H. Rasul Department of Biology, Faculty of Science, Soran University, Kurdistan Region.
Shorsh M. Abdulla Department of Biology, Faculty of Science, Soran University, Kurdistan Region.
Ismael A. Ismael Department of Biology, Faculty of Science, Soran University, Kurdistan Region.

Keywords: Alanine aminotransferase, liver injury, testosterone.

Abstract

The experimental study of this paper was designed to investigate male rat susceptibility to liver injury. A combination of two experimental animal models (Lead acetate for tissue injury (80 mg / L) and castration) had been used on twenty male rats, they were divided into two groups sham (n = 10); castrated (n = 10). Results revealed that, liver weight reduced significantly (P < 0.05) in sham group in comparison with castrated rats, but kidney weight changed slightly. Also, serum aminotransferase (AST) was significantly higher in sham versus castrated rats. Neither alanine aminotransferase (ALT) and alkaline phosphatase (ALP) nor malondialdehyde (MDA) changed. In conclusion, the absence of male sex hormone would delay tissue injury of male rat organs especially liver organ.

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Author Biographies

Sarkawt Hamad, Department of Biology, Faculty of Science, Soran University, Kurdistan Region.

Sarkawt H. Hamad is an assistant lecturer and under graduate coordinator at the Department of Biology, Faculty of science, Soran university since 2014. He has a B.Sc. and M.Sc. Degree in Biology – Animal physiology. His main research area is physiology and He is very interested in neurophysiology investigations.

Karwan I. Othman, Ashti Hospital, Soran, Erbil, Ministry of Health, Kurdistan Region.

Karwan I. Othman is an assistant lecturer at the department of Biology, Faculty of Science, Soran University since 2014. He has B.Sc. and M.Sc. degree in biology. His main research area is sexual hormone related to liver cancer. Karwan is a member at the Kurdistan biology Syndicate.

Karwan J. Hamad, Department of Biology, Faculty of Science, Soran University, Kurdistan Region.

Karwan J. Hamad is a lecturer at the Soran technical institute – nursing department and He is a manager of Ashti general hospital since 2013. He has B.Sc. and M.Sc. degree in Medical science. His main research area is Physiology and cancer disease.

Balkes H. Rasul, Department of Biology, Faculty of Science, Soran University, Kurdistan Region.

Balkes H. Rasul is an assistant lecturer at the Department of Biology, Faculty of science, Soran university since 2014. She has a B.Sc. and M.Sc. Degree in Biology. Her main research area is Phycolimnology.

Shorsh M. Abdulla, Department of Biology, Faculty of Science, Soran University, Kurdistan Region.

Shorsh M. Abdulla is an assistant lecturer at the department of biology, Faculty of Science, Soran University since 2013. He has B.Sc. Degree in plant production and High Diploma degree in Plant Breeding and M.Sc. Degree in Phytochemistry-Medicinal Plant. His main research area is Phytochemical extraction of medicinal plant and investigating biological activity of plant secondary metabolite products.

Ismael A. Ismael, Department of Biology, Faculty of Science, Soran University, Kurdistan Region.

Ismael A. Ismael is an assistant lecture at the department of Biology, Faculty of Science, Soran University since 2015. He has B.Sc. in animal wealth and M.Sc. degree in poultry nutrition. His main research area is sexual hormone related to liver cancer. Ismael is member at the Kurdistan agriculture Syndicate.

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