Synthesis of New Series of Pyrazoline, and Study their Kinetics and Reaction Mechanism

  • Kosrat N. Kaka Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region – F.R. Iraq http://orcid.org/0000-0002-6379-9775
  • Salam G. Taher Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region http://orcid.org/0000-0001-9583-3432
  • Wali M. Hamad Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region
  • Aram H. Ibrahim Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region
DOI: https://doi.org/10.14500/aro.10508
Keywords: Pyrazolines, Kinetics, Mechanism, Chalcones, Compensation effect, Thiosemicarbazide, Claisen and Michael Pathway.

Abstract

A new series of novel pyrazoline compounds were synthesized by addition of thiosemicarbazide to the 2,6-dibenzylidenecyclohexanone (Chalcone) and its para substituted derivatives. This study was conducted for four purposes. Firstly, a series of five membered ring pyrazoline compounds were synthesized and the structure of all new products obtained are supported by spectral data (1H-NMR, 13CNMR, IR and UV-Vis.), and the effect of substituents were studied. Secondly, the reaction kinetics of the new synthesized compounds were studied to investigate the reaction mechanism pathway and order of the reaction; it was found that, the reaction undergoes via Claisen route of mechanism with first-order reaction. Thirdly, the thermodynamics of the reaction were studied, the rate of the reaction, Arrhenius parameters (A), and thermodynamic parameters for activation includes (free energies (Ea), entropies (ΔS#), and Gibbs free energy (ΔG#) were estimated. Finally, the compensation effect was also studied, and found the same pathway for all of the synthesized pyrazoline compounds.

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Author Biographies

Kosrat N. Kaka, Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region – F.R. Iraq

Kosrat N. Kaka is a lecturer at the department of Chemistry, Faculty of Science and Health, Koya University. He got the B.Sc. degree in General Educational Chemistry from Salahaddin University in 2001, the M.Sc. degree from Koya University in 2008, and the Ph.D. degree in Physical Chemistry from Mosul University in 2017.His research interest mainly based on Organic and physical Chemistry, this includes the synthesis and physical studies of these synthesized compounds with estimation a suitable mechanism. Dr. Kosrat is now the Vice Dean at the Faculty of Science and Health, Koya University.  

Salam G. Taher, Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region

Salam Ghafour Taher is an Assistant Professor at the Department of Chemistry, Faculty of Science and Health, Koya University. He got the B.Sc. degree in General Educational Chemistry from Salahaddin University in 2003, the M.Sc. degree from Bangor University (United Kingdom) in 2007, and the Ph.D. degree in Synthetic Organic Chemistry from Bangor University in 2014. His research interest mainly based on Synthetic Organic Chemistry, this includes the enantiopure synthesis of biologically active compounds (bacterial cell wall components, drugs) and isolation, characterization of biologically important natural products.

Wali M. Hamad, Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region

Wali M. Hamad is a professor at the department of Chemistry, Faculty of Science and Health, Koya University. He got B.Sc. degree in General Educational Chemistry from Salahaddin University in 1987, the M.Sc. degree in General Educational Chemistry from Salahaddin University in 1991, and the Ph.D. degree in Physical Chemistry from Baghdad University in 2001. His research interest mainly based on Organic and physical Chemistry (Liquid crystal), this includes the synthesis and physical studies of these synthesized compounds with estimation a properties of LC. REcently, Prof. Wali is the president of Koya University. 

Aram H. Ibrahim, Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region

Aram H. Ibrahim is a researcher in the Department of Chemistry, Faculty of Science and Health, Koya University.

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ARO Journal: Volume 7, No. 2 (2019)
Published
2019-12-10
How to Cite
Kaka, K. N., Taher, S. G., Hamad, W. M. and Ibrahim, A. H. (2019) “Synthesis of New Series of Pyrazoline, and Study their Kinetics and Reaction Mechanism”, ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 7(2), pp. 5-13. doi: 10.14500/aro.10508.
Issue
Vol. 7 No. 2 (2019): Issue Thirteen
Section
Articles

Copyright (c) 2019 Kosrat N. Kaka, Salam G. Taher, Wali M. Hamad, Aram H. Ibrahim

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