Investigating the Role of Metoclopramide and Hyoscine-N-Butyl Bromide in Colon Motility

Keywords: Acetylcholine, Colon, DFT, Hyoscine-N butyl bromide, Metoclopramide


Metoclopramide is a treatment for gastroenteritis accompanied by vomiting. Hyoscine-n-butyl bromide as an anticholinergic agent causes inhibition of the acetylcholine (Ach) by acting on muscarinic receptors. The study aims to ascertain how metoclopramide affects Ach-induced cortical motility and also investigates the effects of metoclopramide alone and in combination with hyoscine-n-butyl bromide drug effects on colon motility. In this study, 1 cm of colon tissue width was cut, 2 cm long strips were made, and both sides of the tissue were secured with surgical silk at both ends of isolated bath tissues of isolated organs with (1g) tension to the suspended instrument that recorded isometric contractions. Tissue fixation is followed by drug addiction: Ach, metoclopramide, and hyoscine-N-butyl bromide. The tissue was treated with metoclopramide and hyoscine-n-butyl bromide and excess Caine for 10 min. The results show changes in colon frequency, peak-to-peak, and amplitude levels for metoclopramide, hyoscine-N-butyl, and metoclopramide and hyoscine. Apaired T-test statistically analyzes the results. Metoclopramide by itself, as well as in combination with hyoscine-n-butyl bromide, increases colon motility and induces Ach release. In addition, an analysis of the physicochemical characteristics of hyoscine-n-butyl bromide and metoclopramide molecules is conducted. The study includes theoretical calculations of electronic parameters for both protonated and unprotonated forms of these molecules in both gaseous and aqueous environments. These results show the potential use of metoclopramide as a therapeutic option for gastroenteritis with vomiting, warranting additional study, and clinical evaluation. The research also reveals hyoscine-n-butyl bromide and metoclopramide’s molecular features by their physicochemical properties.


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Author Biographies

Sleman Y. Omar, Department of Biology, College of Science, University of Raparin, Sulaymaniyah, Iraq

Sleman Yousif Omar is an assistant lecturer at the Department of Biology, College of Science, University of Raparin. He got a B.Sc. degree in Biology and an M.Sc. degree in Medical Human Physiology. His research interests are in Physiology, Biochemistry, and Hematology.

Dyari M. Mamand, Department of Physics, College of Science, University of Raparin, Sulaymaniyah, Iraq

Dyari M. Mamand is an assistant Lecturer at the Department of General & Applied Physics, Faculty of Science, University of Raparin. He got the B.Sc. degree in Salahaddin University-Erbil, the M.Sc. degree from Firat University.

Rebaz A. Omer, Department of Chemistry, Faculty of Science and Health, Koya University, Danielle Mitterrand Boulevard, Koya KOY45, Kurdistan Region – F.R. Iraq

Rebaz A. Omer is a Lecturer at the Department of Chemistry, Faculty of Health and Science, Koya University. He got the B.Sc. degree in Chemistry, the M.Sc. degree in Organic Chemistry, and the Ph.D. degree in Organic and Computational Chemistry His research interests are in Organic Synthesis, DFT, and computational chemistry.

Rzgar F. Rashid, Department of Medical Laboratory Science, College of Science, Knowledge University, Erbil, 44001, Iraq

Rzgar F. Rashid is a lecturer at the Department of medical laboratory science, College of Science, Knowledge University. He got the B.Sc. degree in animal science, the M.Sc. degree in biology science and the Ph.D. degree in biology science. His research interests are in general biology, physiology. hematology and aquatic science.

Musher I. Salih, Department of Chemistry, Faculty of Science and Health, Koya University, Danielle Mitterrand Boulevard, Koya KOY45, Kurdistan Region – F.R. Iraq

Musher I. Salih is a Lecturer at the Department of Chemistry, Faculty of Science and Health, Koya University. He got the B.Sc. degree in Chemistry, the M.Sc. degree in Biochemistry and the Ph.D. degree in Biochemistry. His research interests are in Clinical Biochemistry and Biochemistry.



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How to Cite
Omar, S. Y., Mamand, D. M., Omer, R. A., Rashid, R. F. and Salih, M. I. (2023) “Investigating the Role of Metoclopramide and Hyoscine-N-Butyl Bromide in Colon Motility”, ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY, 11(2), pp. 109-115. doi: 10.14500/aro.11375.