Changes in the Levels of Some Biochemical Parameters in the Serum of Children in Response to the Giardiasis Infection

Sarmad N. Mageed


Giardiasis is one of the most common intestinal protozoan infections worldwide. The study aimed to determine the levels of a number of biochemical parameters in the sera of children with giardiasis without receiving any medication for the treatment of giardiasis or intestinal helminthic infections in the previous 7 days. The study conducted 34 (19 females and 15 males) children and 34 (18 females and 16 males) healthy children as a control group. The mean ages of infected children and control groups were 8 ± 2 and 7 ± 2 years, respectively. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, sodium, potassium, uric acid, and albumin were determined. AST level in males was significantly higher than healthy children control (14.20 ± 1.896 and 10.06 ± 0.699), respectively (P < 0.05), and no significant difference in females was noticed whereas the significant increases in ALT level were found when compared to control (12.43 ± 0.806 and 8.666 ± 0.449), for female, respectively, whereas no significant change in males was observed. Creatinine levels showed significant decrease in females when compared to control (57.72 ± 1.170 and 73.37 ± 1.635) (P ≤ 0.001), respectively.


Biochemical parameters, Children, Giardiasis, Males and females

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Abdumadjidova, S.U., and Inoyatova, F.I., 1998. Effects of Giardia lamblia infestation on the clinical course of chronic hepatitis B. The Turkish Journal of Gastroenterology, 1, pp.24-27.

Al-Mekhlafi, M.H., Azlin, M., Aini, U.N., Shaik, A., Sa’iah, A., Fatmah, M., and Rozlida, A., 2005. Giardiasis as a predictor of childhood malnutrition in Orang Asli children in Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99(9), pp.686-691.

Baghaei, M., 2015. Hypoproteinaemia and Edema Due to Giardiasis. Iranian Journal of Medical Sciences, 28(2), pp.98-99.

Bansal, D., Bhatti, H., and Sehgal, R., 2005. Altered lipid parameters in patients infected with Entamoeba histolytica, Entamoeba dispar and Giardia lamblia. British Journal of Biomedical Science, 62(2), pp.63-65.

Bogitsh, B.J., Carter, C.E., and Oeltmann, T.N., 2013. Human Parasitology. Academic Press, Amsterdam.

Botero-Garcés, J.H., García-Montoya, G.M., Grisales-Patiño, D., AguirreAcevedo, D.C., and Álvarez-Uribe, M.C., 2009. Giardia intestinalis and nutritional status in children participating in the complementary nutrition program, Antioquia, Colombia, May to October 2006.

Revista do Instituto de Medicina Tropical de São Paulo, 51(3), pp.155-162. Burke, J.A., 1975. Giardiasis in childhood. American Journal of Diseases of Children, 129(11), pp.1304-1310.

Burtis, C.A., and Bruns, D.E., 2015. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics (Fundamentals of Clinical Chemistry (Tietz). 7th ed. Saunders, Elsevier Inc., United States of America, p.1103.

Cantey, P.T., Roy, S., Lee, B., Cronquist, A., Smith, K., Liang, J., and Beach, M.J. (2011), Study of nonoutbreak giardiasis: Novel findings and implications for research. The American Journal of Medicine, 124(12), pp.e1171-1175.

Cervello, A., Alfaro, A., and Chumillas, M.J., 1993. Hypokalemic myopathy induced by Giardia lamblia. New England Journal of Medicine, 329(3), pp.210-211.

Charalabopoulos, K., Charalabopoulos, A., Papadopoulou, C., and Papalimneou, V., 2004. Giardia intesinalis: A new pathogen with possible link to Kikuchi Fujimoto disease. An additional element in the disease jigsaw. International Journal of Clinical Practice, 58(12), pp.1180-1183.

Cheesbrough, M., 1987. Medical Laboratory Manual for Tropical Countries. 2nd ed. Elsevier Science and Technology Books, Amsterdam. Craun, G.F., 1984. Waterborne Outbreaks of Giardiasis Giardia and Giardiasis. Springer, Berlin, pp.243-261.

Cusack, M.A., O’Mahony, M.S., and Woodhouse, K., 2001. Giardia in older people. Age and Ageing, 30(5), pp.419-421.

DiBartola, S.P., Johnson, S.E., Davenport, D., Prueter, J., Chew, D., and Sherding, R., 1985. Clinicopathologic findings resembling hypoadrenocorticism in dogs with primary gastrointestinal disease. Journal of the American Veterinary Medical Association, 187(1), pp.60-63.

Farthing, M., Mata, L., Urrutia, J.J., and Kronmal, R.A., 1986. Natural history of Giardia infection of infants and children in rural Guatemala and its impact on physical growth. The American Journal of Clinical Nutrition, 43(3), pp.395-405.

Geovese, A., Spadaro, G., Santoro, L., Rippa, P.G., Onorati, A., and Marone, G., 1996. Giardiasis as a cause of hypokalemic myopathy in congenital immunodeficiency. International Journal of Clinical and Laboratory Research, 26(2), pp.132-135.

Goka, A., Rolston, D., Mathan, V., and Farthing, M., 1990. The relative merits of feacal and duodenal juice microscopy in the diagnosis of Giardia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84(1), pp.66-67.

Halliez, M., and Buret, A.G., 2013. Extra-intestinal and long term consequences of Giardia duodenalis infections. World Journal of Gastroenterology, 19(47), pp.8974-8985.

Hesham, M., Edariah, A., and Norhayati, M., 2004. Intestinal parasitic infections and micronutrient deficiency: A review. The Medical Journal of Malaysia, 59(2), pp.284-293.

Heyworth, M., 1996. Giardiasis. Weatherall, D.J., Ledingham, J.C.C., Warrell, D.A., editorss. Oxford Textbook of Medicine. 3rd ed., Vol. 1. Oxford University Press, Oxford, pp.870-880.

Jasinska, G., and Granicki, O., 1982. Biliary-hepatic giardiasis and viral hepatitis. Pediatria Polska, 57(12), pp.1083-1085.

Júlio, C., Vilares, A., Oleastro, M., Ferreira, I., Gomes, S., Monteiro, L., Nunes, B., Tenreiro, R., and Ângelo, H., 2012. Prevalence and risk factors for Giardia duodenalis infection among children: A case study in Portugal. Parasites and Vectors, 5(1), p.22.

Kasim, A.A., and Elhelu, M.A., 1983. Giardiasis in Saudi Arabia. Acta Tropica, 40(2), pp.155-158. Khudair, H.T., 2010. Prevalence and related risk factors for Giardia lamblia infection among children with acute diarrhea in thi-qar, southern Iraq. Thi-Qar Medical Journal, 4(4), pp.68-74.

Koot, B.G., ten Kate, F.J., Juffrie, M., Rosalina, I., Taminiau, J.J., and Benninga, M.A., 2009. Does Giardia lamblia cause villous atrophy in children? A retrospective cohort study of the histological abnormalities in giardiasis. Journal of Pediatric Gastroenterology and Nutrition, 49(3), pp.304-308.

Korman, S.H., Bar-Oz, B., Mandelberg, A., and Matoth, I., 1990. Giardiasis with protein-losing enteropathy: Diagnosis by fecal [alpha] 1-antitrypsin determination. Journal of Pediatric Gastroenterology and Nutrition, 10(2), pp.249-252.

Krajničáková, M., Kováč, G., Kostecký, M., Valocký, I., Maraček, I., Šutiaková, I., and Lenhardt, Ľ., 2003. Selected clinico-biochemical parameters in the puerperal period of goats. Bulletin of the Veterinary Institute in Pulawy, 47, pp.177-182.

Kremery, V., Brix, M., and Gocar, E., 1989. Elevated indicators of liver metabolism in patients with giardiasis. Vnitr̆ní lékar̆ství, 35(5), pp.479-482.

Kulcu, R., and Yur, F., 2003. A study of some serum mineral levels before and during pregnancy and during lactation period of sheep and cattle. Biological Trace Element Research, 92(3), pp.275-279.

Lee, M., 2009. Basic Skills in Interpreting Laboratory Data. American Society of Health-System Pharmacists, Bethesda, MD. Magdieva, S., Asletdinova, N., and Ziganshina, N., 1984. Effect of hymenolepiasis and enterobiasis on the course of viral (infectious) hepatitis in children. Meditsinskaia Parazitologiia i Parazitarnye Bolezni, 5, pp.31-35.

Mel’nik, G., 1985. Viral hepatitis and lambliasis. Klinicheskaia Meditsina, 63(5), pp.99-102.

Melit, L.E., Marginean, C.O., Dinca, A., Damian, R., and Marginean, C.D., 2017. Protein-losing enteropathy after infectious enterocolitis in child-a case report and a review of the literature. Romanian Journal of Infectious Diseases, 20(1), pp.26-30.

Mildvan, D., Gelb, A.M., and William, D., 1977. Venereal transmission of enteric pathogens in male homosexuals: Two case reports. JAMA, 238(13), pp.1387-1389.

Miller, L.C., and Hendrie, N.W., 2000. Health of children adopted from China. Pediatrics, 105(6), p.e76. Misra, P., Kumar, A., Agarwal, V., and Jagota, S., 1995. A comparative clinical trial of albendazole versus metronidazole in giardiasis. Indian Pediatrics, 32, pp.291-291.

Mondal, D., Minak, J., Alam, M., Liu, Y., Dai, J., Korpe, P., and Petri, W.A., 2012. Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clinical Infectious Diseases, 54(2), pp.185-192.

Nash, T.E., Herrington, D.A., Losonsky, G.A., and Levine, M.M., 1987. Experimental human infections with Giardia lamblia. Journal of Infectious Diseases, 156(6), pp.974-984.

Nematian, J., Gholamrezanezhad, A., and Nematian, E., 2008. Giardiasis and other intestinal parasitic infections in relation to anthropometric indicators of malnutrition: A large, population-based survey of schoolchildren in Tehran. Annals of Tropical Medicine and Parasitology, 102(3), pp.209-214.

Osterholm, M.T., Forfang, J.C., Ristinen, T.L., Dean, A.G., Washburn, J.W., Godes, J.R., and McCullough, J.G., 1981. An outbreak of foodborne giardiasis. New England Journal of Medicine, 304(1), pp.24-28.

Özçay, F., Harmanci, K., and Özbek, N., 2013. Giardiasis as the cause of oedema and hypoproteinaemia in a child. Annals of Tropical Paediatrics: International Child Health, 22(1), pp.63-65.

Prado, M., Cairncross, S., Strina, A., Barreto, M.L., Oliveira-Assis, A., and Rego, S., 2005. Asymptomatic giardiasis and growth in young children; a longitudinal study in Salvador, Brazil. Parasitology, 131(1), pp.51-56.

Ragbetli, C., Tanritanir, P., Yilmaz, H., Yoruk, I., and Ozdemir, H., 2014. Effect on biochemical parameters in naturally infected calves with giardiasis after treatment with albendazole in Van Province, Turkey. Indian Journal of Animal Research, 48(1), pp.38-44.

Rosa, L., Gomes, M., Mundim, A., Mundim, M., Pozzer, E., Faria, E., and Cury, M., 2007. Infection of dogs by experimental inoculation with human isolates of Giardia duodenalis: Clinical and laboratory manifestations. Veterinary Parasitology, 145(1), pp.37-44.

Rosenberg, I., Solomons, N., and Schneider, R., 1977. Malabsorption associated with diarrhea and intestinal infections. The American Journal of Clinical Nutrition, 30(8), pp.1248-1253.

Roxström-Lindquist, K., Palm, D., Reiner, D., Ringqvist, E., and Svärd, S.G., 2006. Giardia immunity an update. Trends in Parasitology, 22(1), pp.26-31.

Sandstead, H.H., Shukry, A.S., Prasad, A.S., Gabr, M.K., EL Hifney, A., Mokhtar, N., and Darby, W.J., 1965. Kwashiorkor in Egypt: I. Clinical and biochemical studies, with special reference to plasma zinc and serum lactic dehydrogenase. The American Journal of Clinical Nutrition, 17(1), pp.15-26.

Simsek, Z., Zeyrek, F.Y., and Kurcer, M., 2004. Effect of Giardia infection on growth and psychomotor development of children aged 0-5 years. Journal of Tropical Pediatrics, 50(2), pp.90-93.

Sotto, A., Alvarez, J., and Garcia, B., 1990. Acute hepatic lesion caused by Giardia lamblia. Revista Española de Enfermedades Digestivas, 77(1), pp.24-28.

Sotto, E.A., and Gra, O.B., 1986. Giardia lamblia and chronic hepatitis. Revista Española de Enfermedades Digestivas, 69(6), pp.583-586.

Tanyuksel, M., Sayal, A., and Aydin, A., 1995. Trace element levels in some parasitic disease. Acta Parasitol Turcica, 19, pp.315-321.

Teixeira, J.C., Heller, L., and Barreto, M.L., 2007. Giardia duodenalis infection: Risk factors for children living in sub-standard settlements in Brazil. Cadernos de Saúde Pública, 23(6), pp.1489-1493.

Telichko, A., Mirzoian, M., and Nersesova, A., 1973. Course of infectious hepatitis in patients with biliary tract lambliasis. Voen Med Zh, 2, pp.56-57.

Thapa, B.R., and Walia, A., 2007. Liver function tests and their interpretation. The Indian Journal of Pediatrics, 74(7), pp.663-671.

Willard, M., Fossum, T., Torrance, A., and Lippert, A., 1991. Hyponatremia and hyperkalemia associated with idiopathic or experimentally induced chylothorax in four dogs. Journal of the American Veterinary Medical Association, 199(3), pp.353-358.

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