Synthesis and Antibacterial Activity of Isatin Schiff Base Derivative with 3-Aminoacetophenone and its Ni(II), Co(II) Transition Metals Complexes

Eman I. Alsalihi; Aeed S. Al-Fahdawi

doi:10.14500/aro.10245

Eman I. Alsalihi Department of Chemistry, Faculty of Science and Health, Koya university, Kurdistan Region http://orcid.org/0000-0001-8991-0702
Aeed S. Al-Fahdawi Department of Chemistry, College of Education for Women, University of Anbar, Ramadi, Anbar http://orcid.org/0000-0002-2132-865X

Keywords: 3-aminoacetophenone, Bidentate ligand and (N) donor atoms, Isatin, Schiff base

Abstract

The (E)-3-(3-acetylphenylimino) indolin-2-one (Bidentate) ligand type [HL], has been prepared from Isatin and 3-aminoacetophenone in the presence of KOH. In general, the ligand contains oxygen (O) and nitrogen (N) donor atoms. The reaction of Isatin and 3-aminoacetophenon was carried out in ethanol by condensation reaction at 80°C with reflux for 4 h, to form [HL] ligand type. This ligand has been used to prepare Ni^II and Co^II complexes in the ratio of 1:1 metal-ligand. All compounds have been characterized by spectroscopic methods (Fourier transform infrared and ultravioletvisible), C.H.N, thin-layer chromatography, mass spectrum, X-ray diffraction, magnetic moment, conductivity measurements and milting point, the synthesized ligand and its metal complexes have been tested for their antibacterial activity against Staphylococcus aureus and Bacillus subtilis using agar disc diffusion method. The ligand and its complexes showed significant activities against S. aureus and B. subtilis. Our study revealed the formation of four coordinate square planar complexes around Ni^II and Co^II metal ions.

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Author Biographies

Eman I. Alsalihi, Department of Chemistry, Faculty of Science and Health, Koya university, Kurdistan Region

Dr. Eman Ibraheem Alsalihi is a Lecturer, joined the Department of Chemistry, Faculty of Science and HEalth at Koya University in 2009. She has a B.Sc. degree in Chemistry, M.Sc. degree in Inorganic Chemistry and Ph.D. degree in Inorganic Chemistry. She is a membership of the ACS (American Chemical Society) since 2015 . Dr. Eman has (10) published Journal articles.

Aeed S. Al-Fahdawi, Department of Chemistry, College of Education for Women, University of Anbar, Ramadi, Anbar

Dr. Aeed Salih Mohammed is an Assistant Professor. He joined the Department of Chemistry, College of Education for Women at the the University of Anbar in 2001. He has a B.Sc. degree in Chemistry, M.Sc. degree in Inorganic Chemistry and Ph.D. degree in Inorganic Chemistry, he has (10) published Journal Articles.

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Synthesis and Antibacterial Activity of Isatin Schiff Base Derivative with 3-Aminoacetophenone and its Ni(II), Co(II) Transition Metals Complexes

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