Kinetics Study of the Formation of Pyrmidine Thione from the Reaction of 2,6-dibenzylidinecyclohexanone and its Derivatives with Thiourea

Kosrat N. Kaka; Abdul Majeed M. Dabbagh; Wali M. Hamad

doi:10.14500/aro.10142

Kosrat N. Kaka Faculty of Science and Health, Koya University, Kurdistan Region http://orcid.org/0000-0002-6379-9775
Abdul Majeed M. Dabbagh Department of Chemistry, College of Science, Mosul University
Wali M. Hamad Department of Chemistry, Faculty of Science and Health, Koya University, Kurdistan Region

Keywords: 2, 6-dibenzylidenecyclohexanone and its derivatives, mechanism route, kinetics study, thiourea, thiopyrimidine.

Abstract

Kinetics of the addition of thiourea to 2,6-dibenzylidenecyclohexanone and its derivatives have been studied. The reaction is found as a pseudo-first order process which includes a nucleophilic attack by thiourea at the carbonyl group of the ketone system to produce the heterocyclic pyrimidine thione "thiopyrimidine" (Claisen route mechanism). The effect of the substituents at the para position of the 2,6-dibenzylidenecyclohexanone and its derivatives on the rate of reaction, at different temperatures, is studied. Arrhenius parameters, entropies, enthalpies and free energies of activations are estimated. A suitable mechanism, which is correspondent with the results and with Claisen routes mechanism, is suggested for this reaction.

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Author Biographies

Kosrat N. Kaka, Faculty of Science and Health, Koya University, Kurdistan Region

Mr. Kosrat is a teaching staff member in the Faculty of Science and Health, Koya University. He is pursuing his Ph.D. study at the Department of Chemistry, Mosul University – F.R. Iraq

Abdul Majeed M. Dabbagh, Department of Chemistry, College of Science, Mosul University

Department of Chemistry, College of Science, Mosul University, F.R. Iraq

Wali M. Hamad, Department of Chemistry, Faculty of Science and Health, Koya University, Kurdistan Region

Dr. Wali Mahmood Hamad is President of Koya University. He was awarded BSc. (1987) in Chemistry, MSc (1990) in Physical chemistry at the University of Salahaddin. Between 1991 and 2004, he was an active academic staff of the Chemistry Department teaching physical chemistry, kinetics, and quantum chemistry. At 1993 he served as chairman of the university cultural committee and between 1995-1997 was appointed as Director of the University printing house. At 2001 he was awarded a PhD degree in field of physical chemistry (Liquid crystal) at the University of Baghdad, and later from May 2004 to November 2010 he has served as dean of the Koya Technical Institute. Beside his job as dean, he lead the Department of Oil Refinery for one year and during this time he worked for establishing the college of science of the Koya university. Dr Hamad is an active member of the Teacher Federation and the Physics and Chemistry Society of Kurdistan. He has a number of scientific articles and books in field of physical chemistry, and advanced thermodynamics as well as in fields of cultural science and politics which appeared in numerous peer-reviewed national and international journals and magazines. In addition, he has presented in numerous internationally peer reviewed conferences.

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